Metalocalypse
Mark HamillSenator Stampingston / Mr. Selatcia (voice)
Victor BrandtGeneral Crozier / Cardinal Ravenwood (voice)
Brendon SmallSkwisgaar Skwigelf / Pickles the Drummer / Nathan Explosion
Tommy BlachaToki Wartooth / William Murderface (voice)
Malcolm McDowellVater Orlaag (voice)
Laraine NewmanNews Anchor / Woman (voice), News Reporter / Grandma / GMILF (voice), Nathan's Grandma (voice), Pickles' Mom (voice), TV Host / Sucubboso Explosionite (voice), Liz Bane (voice), Newscaster (voice), Serveta Skwigelf / Molly / Rose Explosion (voice)
George FisherHippie (voice), Metal Masked Assassin (voice), Angry Customer (voice), Football Player (voice)
James HetfieldFan #1 (voice), Lorkey (voice), Troll (voice), Sniper (voice)
King DiamondEmployee 421 (voice), The Blues Devil (voice), Ronald von Moldenberg (voice), Fast Food Restaurant Manager (voice)
Kirk HammettSmoked Fingers fan (voice), Barkeep (voice), Queen of Denmark (voice)
Jon SchneppAdditional Voices (voice), Dr. Gibbits (voice)
SilenozPrison Inmate (voice), Bobby (voice), Yaneemango Indian (voice)
Angela GossowLavona Sucubboso / Sucubboso Explosionite (voice), Lavona Sucubboso (voice)
Mike Patton
Laura SilvermanRebecca Nightrod (voice), Valerie Vransinn / Grishnack's Assistant (voice)
Devin TownsendAdditional Voices (voice), Teenage Fan at Juice Joint (voice)
ICS VortexYaneemango Indian (voice), Mitch (voice)
Werner Herzog
Brian Posehn
Gene Hoglan
Jeff LoomisMr. Murderface (voice)
Warrel DaneSammy Twinskins (voice)- SSteve SmythSnizzy Bullets (voice)
Andy RichterJ.F. Amarth (voice)- MMike KeneallyDoctor (voice)
Frankie IngrassiaRachel / Sucubboso Explosionite (voice)
Slash
Dave Grohl