What's New Scooby-Doo
Frank WelkerFred Jones / Scooby-Doo (voice)
Casey KasemShaggy Rogers (voice)
Mindy CohnVelma Dinkley (voice)
Grey DeLisleDaphne Blake (voice)
James Arnold TaylorOwen DeCassle / Steve Fortescu (voice), Frankie Martin / Shawn (voice), Prince Qasl Al-Famir / Tourist Son (voice), Dr. Laslow Ostwald / Tad (voice), Burr Batson / Champ Truman (voice), The Scientist (voice), Sonny Les Matines / Guy L'Avorton (voice)
Dee Bradley BakerCrusty McPete / Lighthouse Keeper (voice), Chinese Dragon (voice), Skull / Announcer / M'Lady Moonbeam (voice), Mike (voice), Faceless Phantom / Bull Brassman / Assistant Director (voice), Snow Creature (voice), Menacing Metallic Clown / Gary Snipper (voice), Fish Fiend (voice)
Jeff BennettMr. B (voice), Earnest Bailey / Burglar #1 / Worker #1 (voice), General Niedermeyer / Mr. B / MP Guard #1 (voice), Charles 'Crunchy' Granville / Fritz / Mr. Keenan (voice), Mr. B / Scar / Guard (voice), Feta Cheese Vendor / Major Portsmouth / Shop Owner (voice), Sam / Tailor / Swedish Fan (voice), Roderick Kingston / Writer (voice)
Jennifer HaleHoney Hunsecker / Dr. Joan Goodfew (voice), Thorn (voice), Linda / Gooey-Oh Creature / Zombie Kid #3 (voice), Leora Lasswell (voice), House Computer / Allison (voice), Sue Krose (voice), Meadow / Maize / Knox (voice)
John DiMaggioMike Fury (voice), Sanfran Psycho (voice), Taylor Leland / Police Officer (voice), Malachi Crunch / Titanic Twist (voice), Glasburgh Dragon / Officious Dwarf / Judge (voice)
Tom KennyNatlas (voice), Band Member / Curtis / Fair Headed Boy (voice), Jack Hunter (voice), Sam / Harry Harrison (voice), Clown / Haunted House / Cougar Forest (voice)
Steve BlumMelbourne O'Reilly / Guide (voice), Melbourne O’Reilly (voice), J.T. Page / Steve Powell (voice), Rufus Raucous (voice), Rama Yam / Spencer Johnson (voice)
Lauren TomMandy Dinwiddie (voice), Nancy Chang (voice), Heather Lane (voice)
Kevin Michael RichardsonLloyd Mbuku / Safari Member / Henry Huncecker (voice), Sharky Tazo / Stink Eye (voice), Announcer / Red Guy (voice), Bruce Wilkenson (voice)
Kimberly BrooksElliott Binder (voice), Luna (voice), Phylidia Flanders / Backup Singer #2 (voice), Janet Lawerence / Elliott Binder (voice)
Colleen O'ShaughnesseyJingle (voice), Celia Clyde (voice)
Eddie DeezenGibby Norton (voice)
Nick JamesonLysander Demas / Scary Looking Man (voice), Stu Fortescu / Wrenchfield (voice), Rebel Canyon (voice) (uncredited)
Daran NorrisUgo DiRinaldi / Shopkeeper (voice), Camel Sam / Tourist Dad (voice), Cowardly Lion / Mr. Reed / Sheriff (voice)
Tara StrongTerry / Joe (voice), Alexandra Viggi (voice), Trudy Lowe (voice)
Fred TatascioreSkeleton (voice), Cat Creature (voice), Clyde / Toxic Terror (voice)
Rob PaulsenTravis Knox / MP Guard / PA Announcer (voice), Avery Orenthal / Government Agent (voice), Jamison Steven Ripley / Pan Lute Player / Puny Guy (voice)
Jim CummingsCyrus T. Buford / Crawdad Mike / Joe (voice), Broderick Bosepheus / Humongus Hammer (voice)
Tasia ValenzaBrooke Bjork (voice), Lupe Chesares / Wormian #2 (voice)
Brian TochiJ.J. Hakimoto (voice), Hakimoto (voice)
Pamela AdlonChris / Eddie (voice), Janey / Bobby Blather (voice)
Phil LaMarrToddy Stickfigger / Cabbie (voice), Col. Henry Thomwald / Shaman (voice)
Roger RoseNarrator / Policeman (voice), Sparrow Man / P.A. Announcer (voice)
Carlos AlazraquiLuis Santiago / Umpire (voice), Roberto Torres / Jaime Herrera / Motor Cross Guy #1 (voice)
Mark HamillTommy's Father (voice), Barge Captain (voice)
Taylor LautnerDennis (voice), Ned (voice)
Rachael MacFarlaneConnie Crunch / Spice (voice), Sheila (voice)
Rino RomanoCoral Creature (voice), Captain Treesdale / Keith Dale (voice)
Kevin McDonaldWalter Claphammer (voice), Julian Libris (voice)
Frankie Ryan ManríquezErnie (voice), Jimmy (voice)
John StephensonZelig (voice), Bob Taylor (voice)
John O'HurleyBeavis Bottomczek (voice), Mayor Snipper (voice)
William SchallertFarmer P. / Neville Popenbacher (voice), Professor Pomfrit (voice)
Jane WiedlinBackup Singer #1, Dusk (voice)
Stacy KeachHarold Ling (voice), The Mayor (voice)
Michael GoughDrill Sergeant Payne / MP Guard (voice), Vampire (voice)
John GabrielDr. Zola / Worker (voice), P.A. Announcer (voice)
Moira QuirkMei Ling (voice), Susie Smythe (voice)
Greg EllisDetective Kang (voice), Russian PA Announcer / Nicolai / Bob (voice)
Lindsay PaganoSelf (voice)
Kath SoucieSusan Dinwiddie (voice)
Brian UngerAvalanche Anderson (voice)
Héctor ElizondoDr. Gutierrez (voice)
Dave FoleyLaslow Oswald (voice)
Bumper RobinsonCap N' Robbie / Native Bearer (voice)
Larc SpiesAndy Dinwiddie (voice)
Jesse BorregoLuis Cepeda (voice)
Kerrigan MahanDel Stone (voice)
Rip TaylorMr. Wackypants (voice)
Jason HarrisFlapjack / Announcer (voice)
Josh PeckDamian / Kid / Zombie Kid #2 (voice)- CChris KlugSelf (voice)
Mimi RogersMaura Ravenmane / Helga (voice)
Daryl SabaraTommy / Steve (voice)
Matt LevinTicket Taker / Matt (voice)
David FaustinoCurt Crunch (voice)
Laraine NewmanWor-El (voice)
Corey BurtonGusano Grande (voice)
Jess HarnellLute Player / Shane Flinty / Constable (voice)- BBeng SpiesMurph / Randy Dinwiddie (voice)
Irene BedardCody Long (voice)
Michael HorseLeon Strongfeather (voice)
Billy WestJimmy Proudwolf (voice)
Vanessa MarshallDanica LeBlake (voice)
Jim BelushiAsa Buckwald (voice)
Kathy KinneySheriff Ellen Perkins (voice)
Peter ScolariProfessor Higginson (voice)
M. Emmet WalshJeb (voice)
Teri GarrSandy Gordon (voice)
Bill MumyHarry Noze (voice)
Eddie SantiagoChip Hernandez, Jr. (voice)
Gedde WatanabeVincent Wong (voice)
Kathy GriffinAutumn Summerfield (voice)- MMike PiazzaSelf (voice)
Clyde KusatsuDr. Akira Onodera / Fisherman / Desk Clerk (voice)
MakoThe Ancient One (voice)
Gwendoline YeoLt. Keiko Tanaka (voice)
Benito MartinezHoratio Hidalgo (voice)- JJonathan OsserBilly Blather (voice)
Diedrich BaderUncle Evan (voice)
Jenny McCarthyMarcy (voice)
Rhea PerlmanAgnes (voice)
Paul StanleySelf (voice)
Julia SweeneyAunt Meg (voice)
DeeDee RescherSylvie (voice)
Ryan ShecklerSelf (voice)
Nika FuttermanRutie Banez (voice)
Maurice LaMarcheHaze Ferlenguini / Security Guy (voice)
Pierre BouvierSelf (voice)
Chuck Comeau Self (voice)- DDavid DesrosiersSelf (voice)
Sébastien LefebvreSelf (voice)
Jeff StincoSelf (voice)
Vince CorazzaZeke Zillion (voice)
Susanne BlakesleePenelope Bailey (voice)
Larry DrakeMoss T. Meister / Burglar #2 / Scooby Snax Monster (voice)- EEva AlmosCaptain Corvina Cloyd (voice)
Mikey KelleyMonroe Hopper (voice)- KKathy NaglerSergeant Linda Rauch (voice)
Paul JulianRoad Runner (voice) (archive footage) (uncredited)
Pat FraleyUncle Karl (voice)
James HoranDr. Fleg / Bandit (voice)
Joey Lauren AdamsRachel (voice)
Dan CastellanetaOfficer McBride / Police Officer (voice)
Harland WilliamsGeorge (voice)
JC ChasezSelf (voice)- SSimon PetrieJonas Sulk / Demon Farmer (voice)
Jill TalleyFrida Flora (voice)
Ron PerlmanInspector Malpumpkin / Joe / Frozen Fiend (voice)
Brett HullSelf (voice)
Miranda CosgroveMiranda Wright / Stacy (voice)
Stacie ChanAlex (voice)
Tara LipinskiGrey (voice)
Denzel WhitakerJake / Kid (voice)
James SieLouie Hong Fa (voice)- VVictoria BrunoCindy (voice)
Rodger BumpassAnnouncer / Steve (voice)- SSteve HarwellSelf (voice)
Ben DiskinBenji / Travis / Zombie Kid #1 (voice)
Khary PaytonMitch (voice)