Squidbillies
Dana SnyderGranny Cuyler (voice)- DDaniel McDevittRusty Cuyler (voice)
Dave WillisNarrator / Denny (voice)- TTodd HansonDan Halen (voice)
Patricia FrenchAunt Lil (voice)- BBobby EllerbeeSheriff (voice)
- UUnknown HinsonEarly Cuyler (voice)
- SScott HilleyReverend (voice)
Fred ArmisenMiguel
Charles NapierSheriff (voice)
Danny Baker
Mary KraftMother- EElizabeth CookTammy (voice)
Jason IsbellPastor Nubbins (voice)
Tracy MorganEarly Cuyler (voice)
Jesco WhiteGa-Ga-Pee-Pap Cuyler (voice)- MMax WillisBaby, Macho Man Randy Cuyler (voice)
Jonathan KatzTherapist (voice)
Dan TriandiflouDurwood (voice)
Isaac Hayes IIIPrisoner (voice), Ra (voice)
George LoweAnnouncer (voice)
T-PainT-Pain (voice)- KKevin GillespieKevin Gillespie (voice)
Paul StanleyPaul Stanley GPS (voice)
Patton OswaltTalking Squid (voice)
David Allan CoeDavid Allan Coe (voice)- WWidespread Panic
- DDrive-By Truckers
Chad JohnsonChad Ochocinco (voice)- JJackyl
Billy Joe ShaverMudsy (voice)- ..38 Special
CoolioCoolio (voice)
Jason 'Wee Man' AcuñaWee Man (voice)- EEdward HastingsNed Hastings (voice)
- AArmando RinconiaAuthentic Mexican
Phil Hendrie(voice)- GGeorge RobinsonSnow Daddy (voice)
Lavell CrawfordJudge Jammer (voice)
Anthony 'Citric' Campos(voice)- JJason D. WilliamsSelf
Don BarnesDon Barnes (voice)- DDanny ChaunceyDanny Chauncey (voice)
Larry JunstromLarry Junstrom (voice)
Eric Butterbean EschEric "Butterbean" Esch (voice)- BBillie ReavesMammy (voice)
Mick FoleyThunderclap Cherokee Antoine (voice) (uncredited)- DDomingo S. OrtizDomingo S. Ortiz (voice)
John BellJohn Bell (voice)- TTodd NanceTodd Nance (voice)
- DDave SchoolsDave Schools (voice)
- JJohn "JoJo" HermannJohn Hermann (voice)
- JJimmy HerringJimmy Herring (voice)
Ralphie MayPnut (voice)
Steve EarleSteve Earle (voice)- RRay Wylie HubbardRay Wylie Hubbard (voice)
Shooter JenningsShooter Jennings (voice)- NNikki LaneNikki Lane (voice)
Mojo NixonMojo Nixon (voice)- RRoger Alan WadeRoger Alan Wade (voice)
Lucinda WilliamsLucinda Williams (voice)- BBlayr NiasDr. Anastasia Evertree (voice)